Rapidly Appearing Dark Spots – Dark patches that emerge suddenly and grow or change quickly.Persistent Sores – Wounds that fail to heal even after several weeks.Evolving Moles – Moles that noticeably alter in shape, size, or color over a short period.Itchy, Flaky Areas – Rough, irritated skin that becomes dry, peels, or flakes off.Painful Swelling – Inflamed, reddened skin that is accompanied by sharp discomfort.Painful Blistering Rashes – Unexplained rashes that develop into painful blisters.Unusual Skin Thickening – Areas of skin that become abnormally thick and rough without a clear reason.Yellowing of Skin or Eyes – Jaundice, which could indicate underlying liver problems.